chloride ion channels การใช้

This prevents the opening of chloride ion channels normally encouraged by GABA, reducing the chloride ions'ability to lower a neuron's membrane potential.
Mutations of the CFTR gene affecting chloride ion channel function lead to dysregulation of epithelial fluid transport in the lung, pancreas and other organs, resulting in cystic fibrosis.
Alcohol produces a sedative effect by acting on receptors of the inhibitory neurotransmitter GABA . GABA receptors contain a binding site for GABA, a chloride ion channel, and an additional binding site for alcohol molecules.
Once bound, the benzodiazepine locks the GABA A receptor into a conformation where the neurotransmitter GABA has much higher affinity for the GABA A receptor, increasing the frequency of opening of the associated chloride ion channel and hyperpolarising the membrane.
There is cross tolerance between alcohol, the benzodiazepines, the barbiturates, the nonbenzodiazepine drugs, and corticosteroids, which all act by enhancing the GABA A receptor's function via modulating the chloride ion channel function of the GABA A receptor.